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Updated: Jan 21, 2026

Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
Macular hole after intravitreal bevacizumab injection for choroidal neovascularisation
Hasan Ali Tufan1, Baran Gencer, Selcuk Kara
1Department of Ophthalmology, School of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey. ha_tufan@hotmail.com.
Purpose:
The aim of this study was to report a patient who developed a full-thickness macular hole following intravitreal bevacizumab injection.
Methods:
A 78-year-old patient diagnosed with choroidal neovascularisation (CNV) was treated with intravitreal bevacizumab injection.
Results:
On the first follow-up visit, a decrease in visual acuity was seen and a small full-thickness macular hole with complete resolution of subretinal fluid was observed in optical coherence tomography (OCT). A second intravitreal injection of bevacizumab was performed. At the subsequent visit, a serious loss of visual acuity and limited regression in choroidal neovascularisation was seen. The OCT showed a larger full-thickness macular hole.
Conclusions:
This case demonstrates that intravitreal bevacizumab injection might be responsible for the development of a macular hole. Clinicians should be cautious that a macular hole may be a complication of intravitreal bevacizumab injection.
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