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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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In Vivo Imaging and Tracking of Technetium-99m Labeled Bone Marrow Mesenchymal Stem Cells in Equine Tendinopathy
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Stem cell therapy in veterinary dermatology.

Robert J Harman1

  • 1Vet-Stem, Inc., 12860 Danielson Court, Poway, CA 82064, USA. bharman@vet-stem.com

Veterinary Dermatology
|January 22, 2013
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSCs) from adipose tissue and bone marrow show promise for skin regeneration and treating inflammatory skin conditions. These adult stem cells can differentiate and modulate immune responses, aiding in wound healing and disease treatment.

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Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Dermatology

Background:

  • Adult stem cells, particularly mesenchymal stem cells (MSCs), are versatile and can differentiate into various cell types, including skin cells.
  • MSCs are readily isolated from bone marrow and adipose tissue and secrete cytokines that regulate regeneration.
  • The therapeutic potential of MSCs for skin conditions is increasingly recognized due to their ease of collection and propagation.

Purpose of the Study:

  • To explore the application of mesenchymal stem cells (MSCs) in treating skin damage and diseases.
  • To highlight the use of MSCs in tissue engineering and direct injection for skin repair.
  • To discuss the immunomodulatory effects of MSCs in treating immune-mediated skin conditions.

Main Methods:

  • Utilizing MSCs in tissue-engineered skin constructs for traumatic and ischemic skin damage.
  • Direct injection of MSCs into damaged skin tissue.
  • Systemic administration of MSCs to modulate immune responses in immune-mediated diseases.
  • Employing autologous stem cell sources like adipose tissue and bone marrow.

Main Results:

  • MSCs downregulate inflammatory cytokines and block T-cell activation in immune-mediated diseases.
  • MSCs stimulate proliferation, migration, and repair of local skin cells like keratinocytes and progenitor cells.
  • Clinical trials have shown successful treatment of conditions such as multiple sclerosis, rheumatoid arthritis, and lupus using MSCs.
  • Human and animal studies demonstrate MSCs' efficacy in reconstructive surgery, scar resolution, and skin regeneration.

Conclusions:

  • Mesenchymal stem cells derived from adipose tissue represent a significant advancement in treating diverse skin diseases.
  • The immunomodulatory and regenerative properties of MSCs offer promising therapeutic avenues for skin repair and disease management.
  • Further research and clinical application of MSCs are expected to expand their role in dermatology and regenerative medicine.