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Updated: May 15, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
[Parkinson's disease due to laboral exposition to paraquat]
Angel Gilberto León-Verastegui1
1Salud en el Trabajo, Unidad de Medicina Familiar 45, Instituto Mexicano del Seguro Social, San Luis Potosí, San Luis Potosí, México. angel.leon@imss.gob.mx
Abstract:
Parkinson's disease is considered a neurodegenerative disorder, which involves environmental factors in the etiology of the disease. Such as chemical agents with neuromolecular effect among which is the MPTP (1-methyl-4-phenyl-1, 2, 3, 6 tetra-hydropyridine), MPP (1-methyl-4-phenyl hypyridinium), paraquat, the latter used as a herbicide in the agricultural fields of our country. It has been documented in epidemiological and experimental studies the association of occupational exposure to paraquat and Parkinson's disease. The aim of this paper is to describe a clinical case of occupational medicine in Parkinson's disease in occupationally exposed workers to paraquat, elevating the importance of medical history work, which was the key to the clinical case study.
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