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Related Experiment Videos

Role of cyclic AMP in myocardial cell function.

M L Entman, W B Van Winkle

    Texas Reports on Biology and Medicine
    |January 1, 1979
    PubMed
    Summary

    Agents that increase cyclic adenosine monophosphate (cAMP) are positive inotropic agents. This review explores potential cellular sites where cAMP influences cardiac contractility, considering the heart as a complex system.

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    Area of Science:

    • Cardiology
    • Molecular Biology
    • Cell Physiology

    Background:

    • Agents stimulating cyclic adenosine monophosphate (cAMP) formation are known positive inotropic agents.
    • This suggests cAMP's role in mediating positive inotropic effects in the heart.

    Purpose of the Study:

    • To review potential cellular sites of inotropic intervention.
    • To explore mechanisms of cyclic AMP (cAMP)-mediated effects on myocardial contraction.

    Main Methods:

    • Review of existing literature and in vitro experimental evidence.
    • Analysis of excitation-contraction coupling concepts.
    • Discussion of in vivo-in vitro correlations.

    Main Results:

    • Several cellular sites potentially affected by cAMP-mediated events were identified.
    • The myocardium is proposed as a multicompartmented system with multiple effector sites for cAMP.
    • Experimental data suggests complex regulation beyond simple correlation between cAMP levels and contractility.

    Conclusions:

    • Simple correlations between myocardial cAMP levels and cardiac contractility are insufficient.
    • A multicompartmented model with individual controls for cAMP effector sites is proposed.
    • Challenges in experimental design and the role of linked enzyme systems are discussed.

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