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Nutrient-based dietary patterns and pancreatic cancer risk
Cristina Bosetti1, Francesca Bravi, Federica Turati
1Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri Milan, Italy. cristina.bosetti@marionegri.it
Annals of Epidemiology
|January 22, 2013
Summary
High intake of animal products and refined starches may increase pancreatic cancer risk. Conversely, a diet rich in vitamins and fiber, from fruits and vegetables, shows a protective association against pancreatic cancer.
Area of Science:
- Epidemiology
- Nutritional Science
- Oncology
Background:
- Limited data exist on the impact of combined food and nutrient intake on pancreatic cancer risk.
- Dietary patterns are complex and require sophisticated analysis to understand their association with disease.
Purpose of the Study:
- To investigate the association between dietary patterns and pancreatic cancer risk.
- To identify specific dietary patterns linked to increased or decreased risk of pancreatic cancer using factor analysis.
Main Methods:
- An Italian case-control study involving 326 pancreatic cancer cases and 652 controls.
- Dietary information was gathered using a validated food frequency questionnaire.
- Principal component factor analysis identified four major dietary patterns: animal products, unsaturated fats, vitamins and fiber, and starch-rich.
Main Results:
- The "animal products" pattern showed a positive association with pancreatic cancer (OR=2.03).
- The "starch-rich" pattern also indicated a higher risk (OR=1.69).
- The "vitamins and fiber" pattern demonstrated an inverse association, suggesting a reduced risk (OR=0.55).
- No significant association was found for the "unsaturated fats" pattern (OR=1.13).
Conclusions:
- Diets high in animal products and refined carbohydrates (cereals, sugars) are linked to increased pancreatic cancer risk.
- A diet abundant in fruits and vegetables, rich in vitamins and fiber, is associated with a reduced risk of pancreatic cancer.
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