Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Crossing Over01:34

Crossing Over

Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...
Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Crossing over01:34

Crossing over

Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Crossing Over01:30

Crossing Over

Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I, duplicated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The hourglass of high acuity vision: Cone plasticity at the intersection of time and space shapes the foveola.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Oriented cell divisions induce basal progenitors and regulate neural expansion across tissues and species.

Science advances·2026
Same author

Retinal glia regulate development of the circadian photoentrainment circuit.

Cell reports·2025
Same author

Modeling neurodegeneration in the retina and strategies for developing pan-neurodegenerative therapies.

Molecular neurodegeneration·2025
Same author

Differentially expressed fusogens specify myocyte states to drive myogenesis.

Development (Cambridge, England)·2025
Same author

Chd4 remodels chromatin to control retinal cell type specification and lineage termination.

Development (Cambridge, England)·2025

Related Experiment Video

Updated: May 7, 2026

Generating Chimeric Zebrafish Embryos by Transplantation
21:01

Generating Chimeric Zebrafish Embryos by Transplantation

Published on: July 17, 2009

Progenitor competence: genes switching places.

Michel Cayouette1, Pierre Mattar, William A Harris

  • 1Cellular Neurobiology Research Unit, Institut de Recherches Cliniques de Montréal, Montreal, Quebec H2W 1R7, Canada. michel.cayouette@ircm.qc.ca

Cell
|January 22, 2013
PubMed
Summary

Drosophila neural progenitor cells lose their ability to become specific neurons over time. This loss of competence is linked to changes in the cells' chromatin organization.

More Related Videos

In Vivo Imaging of Transgenic Gene Expression in Individual Retinal Progenitors in Chimeric Zebrafish Embryos to Study Cell Nonautonomous Influences
10:36

In Vivo Imaging of Transgenic Gene Expression in Individual Retinal Progenitors in Chimeric Zebrafish Embryos to Study Cell Nonautonomous Influences

Published on: March 22, 2017

Primordial Germ Cell Transplantation for CRISPR/Cas9-based Leapfrogging in Xenopus
05:34

Primordial Germ Cell Transplantation for CRISPR/Cas9-based Leapfrogging in Xenopus

Published on: February 1, 2018

Related Experiment Videos

Last Updated: May 7, 2026

Generating Chimeric Zebrafish Embryos by Transplantation
21:01

Generating Chimeric Zebrafish Embryos by Transplantation

Published on: July 17, 2009

In Vivo Imaging of Transgenic Gene Expression in Individual Retinal Progenitors in Chimeric Zebrafish Embryos to Study Cell Nonautonomous Influences
10:36

In Vivo Imaging of Transgenic Gene Expression in Individual Retinal Progenitors in Chimeric Zebrafish Embryos to Study Cell Nonautonomous Influences

Published on: March 22, 2017

Primordial Germ Cell Transplantation for CRISPR/Cas9-based Leapfrogging in Xenopus
05:34

Primordial Germ Cell Transplantation for CRISPR/Cas9-based Leapfrogging in Xenopus

Published on: February 1, 2018

Area of Science:

  • Developmental biology
  • Neuroscience
  • Cell biology

Background:

  • Neural progenitor cells (NPCs) in Drosophila exhibit temporal restrictions in their ability to differentiate into specific neuronal subtypes.
  • Understanding the molecular mechanisms that regulate this developmental timing is crucial for comprehending neurodevelopment.

Discussion:

  • Kohwi et al. investigate the role of subnuclear chromatin organization in terminating the early competence of Drosophila NPCs.
  • The study reveals that alterations in chromatin structure correlate with the loss of developmental potential.

Key Insights:

  • Termination of early neuronal competence in Drosophila is associated with dynamic changes in subnuclear chromatin organization.
  • Specific changes in chromatin structure may act as a molecular switch, limiting the differentiation potential of neural progenitor cells.

Outlook:

  • Further research could elucidate the precise molecular players and mechanisms driving these chromatin alterations.
  • Investigating conserved mechanisms in other model organisms could provide broader insights into developmental timing and cell fate decisions.