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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

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Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
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Follicular dendritic cells: origin, function, and different disease-associated patterns.

Sherif A Rezk1, Bharat N Nathwani, Xiaohui Zhao

  • 1Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA 92868, USA. srezk@uci.edu

Human Pathology
|January 22, 2013
PubMed
Summary
This summary is machine-generated.

Follicular dendritic cells (FDCs) form meshworks in lymphoid follicles, presenting antigens to B cells for immune responses. Their meshwork patterns in various disorders may offer diagnostic and prognostic insights.

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Area of Science:

  • Immunology
  • Cell Biology
  • Pathology

Background:

  • Follicular dendritic cells (FDCs) are specialized antigen-presenting cells crucial for lymphoid follicle structure and function.
  • FDCs form a dense three-dimensional meshwork that maintains follicular architecture.
  • Their primary role involves binding and presenting antigens to germinal center B cells, initiating secondary immune responses.

Purpose of the Study:

  • To explore the diverse patterns of FDC meshworks in reactive and neoplastic disorders.
  • To investigate the potential diagnostic and prognostic value of FDC meshwork alterations.
  • To understand the underlying roles of FDCs in different pathological conditions.

Main Methods:

  • Histopathological examination of FDC meshwork patterns.
  • Analysis of FDC distribution and morphology in various lymphoid tissue disorders.
  • Correlation of FDC meshwork characteristics with clinical data (diagnostic and prognostic).

Main Results:

  • Distinct FDC meshwork patterns are observed in different reactive and neoplastic conditions.
  • Alterations in FDC meshwork architecture may reflect underlying pathological processes.
  • The study discusses the potential utility of these patterns in routine diagnostics and prognosis.

Conclusions:

  • FDC meshwork patterns are variable and associated with different lymphoid disorders.
  • Changes in FDC meshwork architecture may serve as a diagnostic or prognostic biomarker.
  • Further research can elucidate the specific roles of FDCs in disease pathogenesis.