Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

Overview
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: The Dynamics of Soil Organic Carbon in Alpine Grasslands Affected by Livestock Grazing Intensity.

Environmental management·2026
Same author

The Dynamics of Soil Organic Carbon in Alpine Grasslands Affected by Livestock Grazing Intensity.

Environmental management·2026
Same author

CBL2/4-CIPK31-mediated phosphorylation of raffinose synthase enhances cold tolerance in Campeiostachys nutans and rice.

Plant physiology·2026
Same author

Congestion, Obesity, and Survival in Chronic Heart Failure.

Journal of cardiac failure·2026
Same author

A Decisive Decade for Cardiovascular Health in Africa: Turning Evidence into System Design.

Global heart·2026
Same author

Congestion and renal function in patients with chronic heart failure.

ESC heart failure·2026

Related Experiment Video

Updated: May 15, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Mast cells and vascular diseases.

Simon Kennedy1, Junxi Wu, Roger M Wadsworth

  • 1Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, G12 8QQ, UK. simon.kennedy@glasgow.ac.uk

Pharmacology & Therapeutics
|January 22, 2013
PubMed
Summary

Mast cells contribute to cardiovascular disease through inflammatory mediators and enzymes. Targeting mast cells offers a potential therapeutic strategy for cardiovascular conditions.

More Related Videos

Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay
08:43

Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay

Published on: June 19, 2018

Isolation of Functional Cardiac Immune Cells
07:26

Isolation of Functional Cardiac Immune Cells

Published on: December 5, 2011

Related Experiment Videos

Last Updated: May 15, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay
08:43

Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay

Published on: June 19, 2018

Isolation of Functional Cardiac Immune Cells
07:26

Isolation of Functional Cardiac Immune Cells

Published on: December 5, 2011

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Cell Biology

Background:

  • Mast cells are increasingly recognized as key players in cardiovascular diseases.
  • Mast cell products, including enzymes (tryptase, chymase) and mediators (cytokines, chemokines), can negatively impact blood vessel structure and promote inflammation.

Purpose of the Study:

  • To investigate the role of mast cells in cardiovascular conditions.
  • To explore mast cells as potential therapeutic targets for cardiovascular disease.

Main Methods:

  • Utilized genetically modified mice lacking mast cells to study their involvement in cardiovascular diseases.

Main Results:

  • Mast cell deficiency in mice provides insights into their contribution to cardiovascular pathology.
  • Mast cell-derived products have detrimental effects on vascular structure and perpetuate inflammation.

Conclusions:

  • Mast cells are significant contributors to cardiovascular disease pathogenesis.
  • Further understanding of mast cell involvement may lead to novel therapeutic interventions for cardiovascular diseases.