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Updated: May 15, 2026

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
Published on: April 11, 2025
CCR9 inhibition does not interfere with the development of immune tolerance to oral antigens
Matthew J Walters1, Karen Ebsworth, Timothy J Sullivan
1ChemoCentryx, Inc., 850 Maude Avenue, Mountain View, CA 94043, United States. mwalters@chemocentryx.com
Abstract:
Recent literature indicates that mice deficient in the chemokine receptor CCR9 (CCR9(-/-) mice) are unable to generate oral tolerance. The present report describes how such inability can be overcome by increasing the dose of oral antigen. Pharmacological inhibition of CCR9 did not affect the generation of oral tolerance, regardless of antigen dose. These results highlight the inadequacy of genetic deletion of CCR9 when predicting the effects of pharmacological CCR9 inhibition on intestinal biology.
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