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An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
The immune system's involvement in obesity-driven type 2 diabetes
Chengyi Jenny Shu1, Christophe Benoist, Diane Mathis
1Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, United States.
Abstract:
Type 2 diabetes is now a worldwide epidemic, strongly correlated with an elevated incidence of obesity. Obesity-associated adipose tissue inflammation is a major cause of the decreased insulin sensitivity seen in type 2 diabetes. Recent studies have shed light on the cross-talk between the immune system and organismal metabolism. This review discusses the connection between inflammation in adipose tissue and systemic insulin resistance, focusing on the roles of innate and adaptive immune cell subsets in the pathogenesis of this metabolic disease.
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