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Published on: February 16, 2016
T1 mapping for detection of left ventricular myocardial fibrosis in hypertrophic cardiomyopathy: a preliminary study
Minjie Lu1, Shihua Zhao, Gang Yin
1Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Insights
T1 mapping imaging effectively evaluates fibrosis severity in hypertrophic cardiomyopathy (HCM) patients. This advanced technique shows higher diagnostic accuracy than traditional late gadolinium enhancement (LGE) imaging for detecting myocardial fibrosis.
Area of Science:
- Cardiovascular Imaging
- Cardiac MRI Techniques
- Myocardial Fibrosis Assessment
Background:
- Hypertrophic cardiomyopathy (HCM) is characterized by myocardial fibrosis.
- Accurate assessment of fibrosis is crucial for managing HCM.
- Traditional imaging methods have limitations in quantifying fibrosis severity.
Purpose of the Study:
- To assess the diagnostic value of T1 mapping imaging.
- To evaluate fibrosis in patients with hypertrophic cardiomyopathy (HCM).
- To compare T1 mapping with late gadolinium enhancement (LGE) imaging.
Main Methods:
- 21 HCM patients and 18 healthy volunteers underwent LGE and T1 mapping MRI.
- Myocardial regions were analyzed for reduced percent of T1 value (RPTV).
- Regions included remote, peri-LGE, halo-like LGE, and typical patchy LGE areas.
Main Results:
- T1 mapping demonstrated significant differences in RPTV across fibrosis severity in HCM.
- T1 mapping showed a higher area under the curve (0.975) than LGE (0.753).
- RPTV in healthy volunteers was comparable to remote LGE areas in HCM patients.
Conclusions:
- T1 mapping imaging is a valuable tool for evaluating fibrosis severity in HCM.
- HCM exhibits a high prevalence of fibrosis with varying degrees of severity.
- T1 mapping offers superior diagnostic performance compared to LGE imaging for fibrosis assessment.
Purpose:
To investigate the diagnostic value of T1 mapping imaging of evaluating fibrosis in patients with hypertrophic cardiomyopathy (HCM).
Materials And Methods:
21 subjects with HCM and 18 healthy volunteers underwent conventional late gadolinium enhancement (LGE) imaging and T1 mapping imaging. The region of myocardium in HCM is divided into remote area of LGE, peri-LGE, LGE (halo-like LGE and typical patchy LGE). These regions combined with normal volunteers' myocardium were calculated by the reduced percent of T1 value (RPTV).
Results:
The RPTV in healthy volunteers was no significant comparing with that in the remote area of LGE in HCM subjects (3.98 ± 3.19 vs. 3.34 ± 2.75, P>0.05). There were significant statistical differences in pairwise among the remote area of LGE, peri-LGE, halo-like LGE and typical patchy LGE in the RPTV (P<0.0001). ROC curves indicated that the T1 mapping imaging has a greater area under the curve comparing with that of traditional LGE imaging (0.975 ± 0.07 vs. 0.753 ± 0.26, P<0.0001).
Conclusions:
HCM has a high prevalence of fibrosis and with varying severity. T1 mapping imaging can be a useful method to evaluate the severity of the fibrosis in HCM.
