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Related Experiment Video

Updated: May 15, 2026

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
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Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

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Elevated 99mTc 3PRGD2 activity in benign metastasizing leiomyoma.

Xiaona Jin1, Yunxiao Meng, Zhaohui Zhu

  • 1Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,1 Shuai Fu Yuan Hu Tong, Beijing, People's Republic of China.

Clinical Nuclear Medicine
|January 22, 2013
PubMed
Summary

Benign metastasizing leiomyoma can present as pulmonary nodules. This case highlights the utility of (99m)Tc 3PRGD(2) imaging in diagnosing these rare lung masses.

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Area of Science:

  • Radiology
  • Nuclear Medicine
  • Pathology

Background:

  • Pulmonary nodules and masses require accurate diagnostic evaluation.
  • Positron Emission Tomography/Computed Tomography (PET/CT) is a key imaging modality.
  • Differentiating benign from malignant lung lesions is crucial.

Observation:

  • A 43-year-old woman presented with pulmonary nodules/masses.
  • PET/CT showed minimal Fluorodeoxyglucose (FDG) activity in the lung masses.
  • Significantly elevated Technetium-99m 3PRGD(2) ((99m)Tc 3PRGD(2)) activity was observed in the soft tissue masses.

Findings:

  • Pathological examination confirmed benign metastasizing leiomyoma.
  • The imaging findings were atypical for malignancy given low FDG uptake.

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Implications:

  • This case underscores the diagnostic value of (99m)Tc 3PRGD(2) in identifying benign metastasizing leiomyoma.
  • Nuclear medicine imaging can offer complementary information to standard PET/CT in specific cases.
  • Further research into novel radiotracers for characterizing pulmonary lesions is warranted.