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Related Experiment Video

Updated: May 15, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

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Published on: March 26, 2019

[Immune-mediated epilepsy and encephalopathy].

C Kramme¹, C G Bien

¹Epilepsie-Zentrum Bethel, Krankenhaus Mara, Maraweg 17-21, 33617 Bielefeld, Deutschland. corinna.kramme@mara.de

|January 22, 2013

Summary

This summary is machine-generated.

Recent advances reveal immune-mediated disorders affecting the central nervous system (CNS) often cause drug-resistant epilepsy. Autoantibodies are key to identifying these conditions, which may respond to immunotherapy.

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Published on: May 8, 2016

Area of Science:

Neuroimmunology
Central Nervous System (CNS) Disorders
Epilepsy Pathogenesis

Context:

Growing understanding of immune system's role in neurological diseases.
Identification of autoantibodies targeting neural surface antigens.
Prevalence of seizures in approximately 80% of immune-mediated CNS disorders.

Purpose:

To highlight recent advancements in understanding immune-mediated grey matter disorders.
To emphasize the link between these disorders and drug-resistant epilepsies.
To discuss the diagnostic significance of autoantibodies.

Summary:

Immune-mediated disorders affecting the central nervous system's grey matter have been increasingly recognized.
These conditions frequently manifest as seizures, often presenting as difficult-to-treat epilepsies.
The discovery of autoantibodies against neural surface antigens is crucial for diagnosis.

Impact:

Autoantibody identification aids in diagnosing specific immune-mediated epilepsies.
Highlights the potential of immunotherapy to overcome antiepileptic drug resistance.
Offers a therapeutic alternative for patients with refractory epilepsy due to immune causes.