Cutaneous adenodermatofibroma: report of 2 cases

Area of Science:

• Dermatopathology
• Oncology
• Histology

Background:

• Dermatofibromas (DFs) are frequent benign fibrohistiocytic skin neoplasms.
• Various subtypes of DFs exist, classified by architectural, cellular, and stromal features.
• A recently identified DF variant exhibits hemosiderotic stroma and apocrine glands.

Observation:

• This study details two additional cases of dermatofibromas.
• These cases presented without hemosiderotic changes but contained entrapped apocrine glandular structures.
• The glandular component's origin within the dermatofibroma was investigated.

Findings:

• The observed dermatofibromas contained entrapped apocrine glands.
• These lesions lacked the hemosiderotic stroma seen in previously described variants.
• A novel term, 'adenodermatofibroma,' is proposed for these specific lesions.

Implications:

• The findings expand the classification of dermatofibroma subtypes.
• Recognizing adenodermatofibromas aids in accurate histopathological diagnosis.
• Understanding the origin of glandular components offers insights into fibrohistiocytic tumor development.