Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

The Role of Ion Channels in Neuronal Computation

The Role of Ion Channels in Neuronal Computation

A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Model-Free Reinforcement Learning Implementation of Decision Making Under Uncertainty by Sequential Sampling.

Neural computation·2026

Same author

A simple model of co-emergence of grid and place fields.

ArXiv·2026

Same author

A simple model of co-emergence of grid and place fields.

bioRxiv : the preprint server for biology·2026

Same author

Lost in Retraining: Closed-Loop Learning and Model Collapse in Exponential Families.

Physical review letters·2026

Same author

Spatial remapping in the subicular complex and entorhinal cortex follows low-dimensional geometric principles.

bioRxiv : the preprint server for biology·2026

Same author

MIF modulates impaired astrocyte distribution in schizophrenia cortical spheroids.

Brain : a journal of neurology·2026

Search research articles

Related Experiment Video

Updated: May 15, 2026

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice

Published on: August 2, 2024

Grid cells require excitatory drive from the hippocampus.

Tora Bonnevie¹, Benjamin Dunn, Marianne Fyhn

¹Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian Brain Centre, Norwegian University of Science and Technology, Trondheim, Norway.

Nature Neuroscience

|January 22, 2013

Summary

Hippocampal inactivation disrupted grid cell firing patterns in the medial entorhinal cortex (MEC). Grid cells lost spatial periodicity and gained head-direction tuning, indicating hippocampal input is crucial for grid formation.

More Related Videos

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices

Published on: November 26, 2012

Related Experiment Videos

Last Updated: May 15, 2026

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice

Published on: August 2, 2024

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices

Published on: November 26, 2012

Area of Science:

Neuroscience
Cognitive Neuroscience
Computational Neuroscience

Background:

Grid cells in the medial entorhinal cortex (MEC) exhibit spatially periodic firing patterns essential for navigation.
The precise mechanisms underlying grid cell firing and its relationship with hippocampal inputs remain incompletely understood.

Purpose of the Study:

To investigate the influence of hippocampal backprojections on the formation and maintenance of grid cell firing patterns.
To elucidate the role of excitatory drive from the hippocampus in spatial coding.

Main Methods:

Recording neural activity from MEC grid cells in rats during temporary hippocampal inactivation.
Utilizing an attractor network model to simulate grid structure emergence and test the impact of external drive removal.

Main Results:

Hippocampal inactivation led to a gradual loss of grid patterns in MEC cells.
Inactivated grid cells shifted from spatial periodicity to head-direction tuning.
These changes correlated with a decrease in grid cell firing rates and were reproducible in computational models by removing external excitatory drive.

Conclusions:

Excitatory input from the hippocampus is a critical prerequisite for the formation and stability of grid cell representations in the MEC.
Disruption of hippocampal drive alters grid cell function, transforming them into head-direction cells.