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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...
The Proteasome01:13

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3 (ubiquitin...

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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

Understanding regeneration through proteomics.

Catarina Franco1, Renata Soares, Elisabete Pires

  • 1Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal.

Proteomics
|January 22, 2013
PubMed
Summary

This review explores how proteomics aids regeneration research. Understanding molecular mechanisms in diverse animals may unlock regenerative potential in mammals, advancing regenerative medicine.

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Area of Science:

  • Regenerative Biology
  • Molecular Biology
  • Proteomics

Background:

  • Regeneration, the regrowth of functional tissue after injury, varies across metazoa.
  • Mammals, particularly the central nervous system (CNS), exhibit limited regenerative capacity compared to organisms like planaria and starfish.
  • Restoring damaged tissues via transplantation is hindered by the complex differentiation of regenerative cells.

Purpose of the Study:

  • To review the contribution of proteomics to understanding regeneration mechanisms.
  • To explore why regeneration is not readily activated in mammals by studying diverse animal models.
  • To highlight the role of posttranscriptional modifications in regeneration.

Main Methods:

  • Proteomic-based approaches are crucial for studying regeneration.
  • Analysis of diverse animal models with varying regenerative capabilities.
  • Investigation of molecular-level regeneration mechanisms.

Main Results:

  • Proteomics offers significant insights into regeneration across different species, tissues, and organs.
  • Posttranscriptional processes, including post-translational modifications (PTMs), are vital in regeneration.
  • Comparative studies reveal key differences in regenerative mechanisms.

Conclusions:

  • Proteomics is instrumental in advancing regeneration research.
  • Understanding diverse regenerative strategies may hold keys to enhancing mammalian regeneration.
  • Further research into molecular mechanisms can drive progress in regenerative medicine.