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Brain metastasis of unknown origin.

C P Chee1

  • 1University Hospital, University of Malaya, Kuala Lumpur.

Singapore Medical Journal
|February 1, 1990
PubMed
Summary

Aggressive treatment for brain metastases with unknown primary sites can improve patient quality of life. Surgical intervention in solitary cases led to significant short-term improvement and a low mortality rate.

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Singapore medical journal·1989

Area of Science:

  • Neurosurgery
  • Oncology
  • Clinical Medicine

Background:

  • Brain metastases represent a significant challenge in neuro-oncology.
  • Identifying the primary tumor site is crucial for effective treatment planning.
  • Unknown primary brain metastases pose diagnostic and therapeutic difficulties.

Purpose of the Study:

  • To evaluate the outcomes of patients with brain metastases of unknown primary origin.
  • To assess the efficacy of aggressive treatment, including surgery, in this patient cohort.
  • To determine the short-term and medium-term survival and quality of life.

Main Methods:

  • Retrospective analysis of 119 patients with brain metastases treated between 1973 and 1984.
  • Focus on cases where the primary tumor site remained unknown.
  • Evaluation of surgical interventions (excision or decompression) for solitary metastases.

Main Results:

  • 33% of cases had unknown primary sites one month post-discharge.
  • Solitary metastases were common, often presenting with neurological signs.
  • Majority of surgically treated patients showed improvement at one month.
  • One-month mortality rate was 3%.

Conclusions:

  • Aggressive management, including surgery for solitary lesions, improves immediate postoperative quality of life.
  • A subset of patients with unknown primary brain metastases can achieve long-term survival.
  • Timely and appropriate neurosurgical intervention is beneficial for selected patients.

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