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Published on: April 21, 2022
Multiple primary malignant neoplasms: multi-center results from Turkey
N A Babacan1, S Aksoy, B Cetin
1Cumhuriyet University Faculty of Medicine, Department of Medical Oncology, Sivas, Turkey.
Summary
The frequency of multiple primary malignant neoplasms (MPMNs) is increasing. This study identified common second primary cancer (SPC) pairs, like breast-gynecologic in females and head and neck-lung in males, emphasizing rigorous evaluation of suspicious lesions.
Area of Science:
- Oncology
- Cancer Epidemiology
Background:
- Multiple primary malignant neoplasms (MPMNs) involve diagnoses of two or more independent primary malignancies.
- The incidence of MPMNs is rising globally.
- Understanding the patterns of second primary cancers (SPCs) is crucial for patient management.
Purpose of the Study:
- To determine the frequency of SPCs in patients with MPMNs.
- To identify the clinical features and common combinations of SPCs.
- To raise physician awareness regarding SPC probabilities.
Main Methods:
- Retrospective analysis of MPMN patients diagnosed between January 1990 and December 2010.
- Data collected from hospital charts across five centers.
- Evaluation of 377 patients with MPMNs.
Main Results:
- The most frequent initial cancers were head and neck, breast, and colorectal.
- The most common SPCs were lung, colorectal, and breast cancers.
- In females, common pairs included breast-gynecologic cancers; in males, head and neck-lung cancers were most frequent.
Conclusions:
- Physicians must maintain high awareness of SPC probabilities.
- Suspicious lesions in patients with a history of cancer warrant thorough evaluation.
- Extensive histopathologic assessment is recommended for suspected second tumors.
