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Updated: May 15, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

The paradoxical functions of B cells and antibodies in transplantation

Marilia I Cascalho1, Brian J Chen, Mandy Kain

  • 1Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. marilia@umich.edu

Journal of Immunology (Baltimore, Md. : 1950)
|January 22, 2013
PubMed

Scarcely anyone would dispute that donor-specific B cells and the Abs that they produce can cause rejection of transplants. Less clear and more controversial, however, is the possibility that donor-specific B cells and the Abs that they produce are one or more means by which transplants can be protected from injury. In this article, we review and discuss this possibility and consider how less well-known functions of B cells and Abs might impact on the design of therapeutics and the management of transplant recipients.

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