[New approaches to local antirheumatic therapy].

Area of Science:

• Rheumatology
• Pharmacology

Background:

• Local antirheumatic therapies are crucial in managing rheumatic diseases.
• Systemic treatments can be complemented by localized approaches.

Purpose of the Study:

• To analyze various local antirheumatic therapies, including drug-induced synovectomy and anti-inflammatory treatments.
• To highlight the role of dimethyl sulfoxide in local therapeutic strategies.
• To explore the potential for improving general therapy outcomes via targeted local interventions.

Main Methods:

• Analysis of existing literature on local antirheumatic treatments.
• Review of drug-induced synovectomy, anti-inflammatory, antifibrotic, and immunosuppressive therapies.
• Focus on dimethyl sulfoxide-based local therapy.

Main Results:

• Local and systemic treatments share common therapeutic mechanisms.
• Local therapy can augment the efficacy of general treatments.
• Dimethyl sulfoxide demonstrates potential in local antirheumatic applications.

Conclusions:

• Local anti-inflammatory therapy is a viable option for most patients with rheumatoid arthritis and other joint diseases.
• Targeted local treatment can enhance the effectiveness of systemic therapy without compromising tolerance.
• Dimethyl sulfoxide warrants further investigation for its role in local antirheumatic treatment.