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Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
Published on: June 13, 2019
[Histiocytic sarcoma:a clinicopathologic study of 4 cases]
Qing-Ming Jiang1, Wen-Wen Zhou, Rong Song
1Department of pathology, Chongqing Cancer Institute, Chongqing, China.
Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi
|January 23, 2013
Summary
Histiocytic sarcoma (HS) is a rare malignant tumor. Diagnosis requires careful examination of tissue morphology, immunohistochemistry, and electron microscopy to distinguish it from other conditions.
Area of Science:
- Oncology
- Pathology
- Immunohistochemistry
Background:
- Histiocytic sarcoma (HS) is a rare malignant neoplasm.
- Understanding its clinicopathologic features is crucial for diagnosis and management.
Observation:
- Reviewed 4 cases of HS with diverse presentations including lymph node, skin/soft tissue, and colon involvement.
- Microscopic examination revealed characteristic tumor cell morphology, including pleomorphism and multinucleation.
- Immunohistochemistry confirmed positivity for histiocyte markers (CD68, CD163) and α-1-ACT, with variable CD45/CD45RO expression.
- Electron microscopy ruled out Birbeck granules, supporting a histiocytic origin.
Findings:
- HS exhibits distinct morphological and immunophenotypic characteristics.
- Prognosis is generally poor, with a high mortality rate within months of diagnosis.
- One case localized to skin/soft tissue showed a favorable outcome.
Implications:
- Accurate diagnosis of HS relies on integrating morphology, immunohistochemistry, and electron microscopy.
- Distinguishing HS from other malignancies is essential for appropriate treatment and patient counseling.
- Further research into HS pathogenesis and targeted therapies is warranted.
