Jove
Visualize
Contact Us

Related Concept Videos

Gut-Brain Axis01:22

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence and risk factors of urinary tract infection in very low birth weight infants.

Journal of neonatal-perinatal medicine·2016
Same author

Increased activation in cingulate cortex in conversion disorder: what does it mean?

Journal of the neurological sciences·2009
Same author

Categories of placebo response in the absence of site-specific expectation of analgesia.

Pain·2006
Same author

The Multi-Source Interference Task: validation study with fMRI in individual subjects.

Molecular psychiatry·2003
Same author

Colocalization of mu-opioid receptors and activated G-proteins in rat cingulate cortex.

The Journal of pharmacology and experimental therapeutics·2001
Same author

Cytology of human caudomedial cingulate, retrosplenial, and caudal parahippocampal cortices.

The Journal of comparative neurology·2001
Same journal

Recognizing Suspected Colonic Hypercompliance in Refractory Constipation When Barostat Testing Is Unavailable-Authors' Reply.

Neurogastroenterology and motility·2026
Same journal

Accuracy of Novice Raters for Esophageal Motility Classifications Using Functional Lumen Imaging Probe Panometry.

Neurogastroenterology and motility·2026
Same journal

Letter to the Editor: "Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial".

Neurogastroenterology and motility·2026
Same journal

The Drought of Evidence for Water Intake to Manage Constipation Symptoms May Be Ending.

Neurogastroenterology and motility·2026
Same journal

L-Carnitine Improves Visceral Hypersensitivity and Colonic Hyperpermeability in a Rat Model of Irritable Bowel Syndrome.

Neurogastroenterology and motility·2026
Same journal

Letter to the Editor: "Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Trial".

Neurogastroenterology and motility·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 15, 2026

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

Inflammatory bowel disease: perspectives from cingulate cortex in the first brain.

B A Vogt1

  • 1Cingulum Neurosciences Institute, Manlius, NY, USA. bvogt@twcny.rr.com

Neurogastroenterology and Motility
|January 23, 2013
PubMed
Summary
This summary is machine-generated.

Brain gray matter volume reductions in Crohn's disease (CD) patients link to abdominal pain, independent of active disease. These findings suggest new therapeutic targets for chronic pain and psychiatric symptoms in CD.

More Related Videos

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
07:29

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Published on: December 29, 2023

Related Experiment Videos

Last Updated: May 15, 2026

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
07:29

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Published on: December 29, 2023

Area of Science:

  • Neurogastroenterology and Motility
  • Neuroscience
  • Psychiatry

Background:

  • Crohn's disease (CD) is associated with chronic pain and psychiatric symptoms.
  • Previous research has not fully elucidated the link between brain structural changes and these symptoms in CD patients, particularly during remission.

Purpose of the Study:

  • To investigate volumetric changes in the brain of patients with Crohn's disease (CD).
  • To establish a correlation between brain gray matter volumes and the experience of abdominal pain in CD patients, independent of active disease or medication.

Main Methods:

  • Volumetric analysis of brain gray matter was performed on patients with Crohn's disease.
  • Correlations were assessed between disease duration and gray matter volumes in specific brain regions.

Main Results:

  • Decreased gray matter volumes were observed in the dorsolateral prefrontal cortex and anterior midcingulate cortex (aMCC).
  • Disease duration negatively correlated with volumes in the subgenual anterior cingulate (sACC), posterior MCC (pMCC), ventral posterior cingulate (vPCC), and parahippocampal cortices.
  • These brain changes were present in patients experiencing ongoing abdominal pain despite being in remission.

Conclusions:

  • Forebrain structural changes are linked to abdominal pain in Crohn's disease, irrespective of active inflammation or drug treatment.
  • Specific cingulate cortex regions (aMCC, sACC, pMCC, vPCC) are implicated in cognitive and emotional processing relevant to CD symptoms.
  • Targeting cingulate-mediated pathways offers potential for novel therapies, including psychotherapy and non-traditional approaches, for chronic pain and psychiatric symptoms in CD.