Related Experiment Video
Updated: May 15, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
Expression of candidate plasticity-related gene 15 is increased following traumatic brain injury
Yalong He1, Guitao Yang, Yangang Wang
1Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Objectives:
Candidate plasticity-related gene 15 (cpg15) is an activity-regulated gene that mediates synaptic plasticity; this study assesses the potential link between cpg15 expression levels and repair and regeneration following traumatic brain injury (TBI).
Methods:
We investigated the expression of cpg15 in the frontal lobe of rats subjected to TBI and sham rats, using the following methods: immunohistochemical analysis, Western blotting, and reverse transcription-polymerase chain reaction.
Results:
CPG15(+) neurons were present in coronal sections of the frontal lobe at Day 1, reached the highest level around Day 14, and maintained elevated levels through Day 21. CPG15 protein and mRNA levels were noticed to increase in a similar temporal pattern. In contrast, rats in the sham group had undetectable levels of CPG15.
Conclusions:
Elevated cpg15 expression in the frontal cortex suggests its possible involvement in regenerative and reparative processes that follow TBI.
More Related Videos
09:29Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury
Published on: September 11, 2017
13:32Laser Capture Microdissection of Enriched Populations of Neurons or Single Neurons for Gene Expression Analysis After Traumatic Brain Injury
Published on: April 10, 2013
Related Concept Videos
Neuroplasticity
Traumatic Brain Injury l: Introduction