Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Histone and non-histone protein acetylation in a tail regeneration model (Ambystoma mexicanum).

Biology open·2026
Same author

A novel fracture lattice in spiny mouse skin facilitates tissue autotomy and regeneration.

bioRxiv : the preprint server for biology·2026
Same author

Characterization of social behavior in the spiny mouse, <i>Acomys cahirinus</i>.

Ethology : formerly Zeitschrift fur Tierpsychologie·2026
Same author

Active mitochondria in healthy spiny mouse fibroblasts resemble megamitochondria and remain resilient across lifespan.

bioRxiv : the preprint server for biology·2025
Same author

Retinoic acid breakdown is required for proximodistal positional identity during axolotl limb regeneration.

Nature communications·2025
Same author

Specific cell states underlie complex tissue regeneration in spiny mice.

bioRxiv : the preprint server for biology·2025
Same journal

Global stabilization of the mitochondrial proteome is associated with extreme anoxia tolerance in Austrofundulus limnaeus WS40NE cells.

BMC biology·2026
Same journal

An endogenous viral element of Aedes albopictus is translated and limits cognate virus.

BMC biology·2026
Same journal

Environmental sex determination in the cyst nematode Globodera pallida defaults to male development.

BMC biology·2026
Same journal

Marine mammals as models for charting the evolution of social vocal rhythm.

BMC biology·2026
Same journal

Associations between immunosenescence and domain-specific cognition in the Health and Retirement Study Harmonized Cognitive Assessment Protocol.

BMC biology·2026
Same journal

Experimental evidence for behavioural cooling as a response to virus infection in an ectothermic vertebrate.

BMC biology·2026
See all related articles

Related Experiment Video

Updated: May 15, 2026

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle
09:14

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

Published on: October 26, 2017

Revisiting the relationship between regenerative ability and aging.

Ashley W Seifert, S Randal Voss

    BMC Biology
    |January 23, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Axolotls, unlike previously thought, can regenerate eye lenses during larval stages. Zebrafish, however, lack this regenerative capacity even as embryos, highlighting evolutionary differences in organ repair.

    Related Experiment Videos

    Last Updated: May 15, 2026

    Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle
    09:14

    Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

    Published on: October 26, 2017

    Area of Science:

    • Developmental Biology
    • Regenerative Medicine
    • Evolutionary Biology

    Background:

    • The ability of newts to regenerate ocular lenses is well-established.
    • Axolotls have historically been considered incapable of lens regeneration.
    • Understanding species-specific regenerative capacities is crucial for advancing regenerative medicine.

    Purpose of the Study:

    • To investigate the lens regeneration potential in axolotls across different life stages.
    • To compare lens regeneration capabilities between axolotls and zebrafish.
    • To explore the evolutionary context of ocular regeneration.

    Main Methods:

    • Comparative analysis of lens regeneration in axolotls (Ambystoma mexicanum) and zebrafish (Danio rerio).
    • Examination of regenerative potential during early larval and embryonic development.
    • Histological and molecular assessments of ocular tissues.

    Main Results:

    • Axolotls demonstrate the ability to regenerate ocular lenses during early larval development.
    • Zebrafish exhibit no capacity for lens regeneration, even at the embryonic stage.
    • Significant differences in regenerative potential were observed between the two species.

    Conclusions:

    • The findings challenge the established view on axolotl lens regeneration.
    • Ocular regeneration capacity varies significantly across amphibian and fish species.
    • Regenerative potential is influenced by developmental stage and evolutionary history, impacting future research in organ regeneration.