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Updated: May 15, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Neonatal paracorporeal lung assist device for respiratory failure
David M Hoganson1, Avihu Z Gazit, Stuart C Sweet
1Division of Pediatric Cardiothoracic Surgery, Department of Surgery, Saint Louis Children's Hospital and Washington University, Saint Louis, St. Louis, Missouri, USA.
Abstract:
Neonates who experience respiratory failure despite maximal ventilatory support have only extracorporeal membrane oxygenation as a rescue therapy, but it has very poor outcomes as a bridge to transplantation. A pumpless lung-assist device has been used in adults as a bridge to lung transplantation. An alternative membrane oxygenator, the Quadrox iD, is a suitable size for neonatal blood flow. Here we report the use of the Quadrox iD membrane oxygenator with central cannulation as a paracorporeal respiratory support therapy for a neonate with alveolar capillary dysplasia awaiting lung transplantation.
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