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Egyptian growth hormone deficient patients: demographic, auxological characterization and response to growth hormone

Nermin Salah1, Soha M Abd El Dayem, Fatma El Mogy

  • 1Pediatrics Department, Cairo University, Cairo, Egypt.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|January 23, 2013
PubMed

Insights

Growth hormone (GH) treatment in growth hormone-deficient (GHD) children shows catch-up growth in the first two years, followed by a plateau. Anthropometric assessment is key for GHD diagnosis and monitoring treatment response.

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Therapy
  • Metabolic Disorders

Background:

  • Growth hormone deficiency (GHD) is a condition affecting children's growth.
  • Accurate diagnosis and monitoring are crucial for effective GHD management.
  • Understanding treatment response patterns is essential for optimizing patient outcomes.

Purpose of the Study:

  • To evaluate the growth response in children with GHD undergoing growth hormone (GH) treatment.
  • To compare the efficacy of GH therapy in patients with complete versus partial GHD.
  • To establish the role of anthropometric assessment in GHD diagnosis and follow-up.

Main Methods:

  • A cohort of 477 children diagnosed with GHD was studied.
  • Longitudinal follow-up ranged from 1 to 6 years with anthropometric assessments every 3 months.
  • Thyroid profiles were monitored every 6 months; statistical analysis used Student's t-test.

Main Results:

  • Children with complete GHD and multiple pituitary hormone deficiencies exhibited significantly shorter stature (height SDS) and greater bone age delay.
  • Patients with complete GHD demonstrated a more robust growth response during the initial two years of GH therapy compared to those with partial GHD.
  • Catch-up growth was observed in the first two years of therapy, after which a growth plateau was reached.

Conclusions:

  • Anthropometric assessment is fundamental for diagnosing and monitoring GHD patients.
  • GH therapy leads to significant catch-up growth in the initial two years, followed by a stabilization of growth.
  • The findings highlight the importance of consistent monitoring for optimizing GH treatment strategies in pediatric GHD.
Abstract

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