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In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

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Related Experiment Video

Updated: May 15, 2026

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts

Published on: March 2, 2017

Frozen embryo transfer: the present practice and beyond.

Anjana Ray Chaudhuri¹, Siddhartha Chatterjee

¹Calcutta Fertility Mission, Kolkata, India.

Journal of Basic and Clinical Physiology and Pharmacology

|January 23, 2013

Summary

Letrozole-induced ovulation induction (OI) offers a cost-effective and simple method for endometrial preparation in frozen embryo transfer (FET) cycles. This approach resulted in higher clinical pregnancy and live birth rates compared to other methods.

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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

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Last Updated: May 15, 2026

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts

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Published on: March 2, 2017

Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model

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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Area of Science:

Reproductive Endocrinology
In Vitro Fertilization (IVF)
Endometrial Biology

Background:

Endometrial preparation is critical for successful in vitro fertilization (IVF), particularly in postmenopausal women undergoing oocyte donation and for frozen embryo transfer (FET) cycles.
Previous IVF attempts, ovarian hyperstimulation syndrome risk, or poor endometrial development necessitate optimized endometrial preparation strategies for FET.

Purpose of the Study:

To evaluate the efficacy of letrozole-induced ovulation induction (OI) as a method for endometrial preparation in frozen embryo transfer (FET) cycles.
To compare the success rates of letrozole-based endometrial preparation with gonadotropin-releasing hormone agonist down-regulation and natural cycle FET.

Main Methods:

A prospective study involving 270 women aged 28-40 undergoing FET due to tubal factors.
Participants were divided into three groups: gonadotropin-releasing hormone agonist down-regulation with hormone replacement therapy (n=100), natural cycle FET (n=55), and letrozole-induced OI for endometrial preparation (n=115).

Main Results:

The letrozole OI group demonstrated significantly higher clinical pregnancy rates and live birth rates compared to the other two groups.
This indicates a superior outcome for endometrial preparation using letrozole in FET cycles.

Conclusions:

Letrozole-induced ovulation induction (OI) provides a viable, cost-effective, and easily administered option for endometrial preparation in FET cycles.
This method shows promise for improving pregnancy and live birth rates in women undergoing FET.