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Updated: May 15, 2026

Troubleshooting and Quality Assurance in Hyperpolarized Xenon Magnetic Resonance Imaging: Tools for High-Quality Image Acquisition
Published on: January 5, 2024
The hidden quality gap in discovery
David Hampton1, Toby Winchester, Pauline Carnell
1SSA & Company Management Consultants, Berkeley Square House, Berkeley Square, London W1J 6BD, UK. dhampton@ssaandco.com
Abstract:
Progress made through technological advances in drug discovery can be undermined by problems with measurement equipment, but it is often difficult to detect the issues without a specific investigation. This article describes the fundamentals of measurement systems analysis and focuses on the issue of precision. Three case studies are given where measurement systems were found to be flawed when subjected to a systematic analysis, and examples of the approaches needed for correction are described.
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