Related Experiment Video
Updated: May 15, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
A new approach to assess drug development performance
Alessandro Rosiello1, Nicola Dimitri, Filippo Fiorini
1ESRC Innogen Centre, University of Edinburgh, United Kingdom. alessandro.rosiello@ed.ac.uk
Abstract:
This article suggests that successful innovation in biopharmaceuticals is strongly related to the ability of firms to move compounds forward along the drug pipeline, relatively to other companies, within the same therapeutic area. We used this intuition to build indicators of performance at the firm-level and use them to conduct empirical analysis that relies upon a comprehensive database. We consider the effect of various factors on drug development performance, including R&D funds allocation across therapeutic areas and the proportion of biological molecules in the drug development portfolio. Subsequently, we show that a correlation exists between our performance variables and the per-capita growth of biopharmaceutical firms' revenues.
Related Concept Videos
Drug Discovery: Overview
Preclinical Development: Overview
In Vitro Drug Release Testing: Overview, Development and Validation
Clinical Trials: Overview
Drug Administration and Therapy Phases: Overview
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
Measurement of Bioavailability: Pharmacodynamic Methods
