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Saethre-Chotzen syndrome associated with defective neutrophil chemotaxis
A Etzioni1, N Obedeanu, A Benderly
1Department of Pediatrics A, Rambam Medical Center, Haifa, Israel.
Acta Paediatrica Scandinavica
|March 1, 1990
Abstract:
An 11-month-old male infant with Saethre-Chotzen syndrome and recurrent respiratory infections is described. Persistent extremely high leukocytosis warranted evaluation of neutrophil functions. It was found that the opsonophagocytic activity was normal, but neutrophil chemotaxis was markedly decreased. Further studies pointed to an intracellular neutrophil defect causing this motility dysfunction.