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Updated: May 15, 2026
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Detection of Mitochondria Membrane Potential to Study CLIC4 Knockdown-induced HN4 Cell Apoptosis In Vitro
Published on: July 17, 2018
⁹⁹mTc-(Me)FGCDEVD, a potential tracer for apoptosis detection
Pierre Bohn1, Florian Mouchard, Jean Rouvet
1Département de médecine nucléaire, Centre Henri Becquerel, 1 rue d'Amiens, 76038 Rouen Cedex, France. pierre.bohn@chb.unicancer.fr
Bioorganic & Medicinal Chemistry Letters
|January 23, 2013
Abstract:
(Me)FGC(Bz)DEVD was radiolabeled with technetium-99m in high yield. This tracer was preferentially accumulated in apoptotic cells in the in vitro studies. Tumor uptake occurred in vivo after cisplatin injection due to the apoptosis induction, which not observed in the untreated tumors. Therefore, (99m)Tc-(Me)FGCDEVD is a potential tracer for apoptosis detection.
