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Benefit of conjugate pneumococcal vaccination in preventing influenza hospitalization in children: a case-control

Angela Domínguez1, Jesús Castilla, Pere Godoy

  • 1Department de Salut Pública, Universitat de Barcelona, Barcelona, Spain. angela.dominguez@ub.edu

The Pediatric Infectious Disease Journal
|January 23, 2013
PubMed

Insights

Pneumococcal conjugate vaccine (PCV) reduced hospitalizations in children under 5 during the 2009-2010 pandemic wave. However, PCV showed no significant benefit in preventing influenza hospitalizations during the 2010-2011 season.

Area of Science:

  • Pediatric Infectious Diseases
  • Vaccinology
  • Epidemiology

Background:

  • Streptococcus pneumoniae plays a role in influenza complications.
  • Pneumococcal conjugate vaccine (PCV) may prevent pediatric hospitalizations due to influenza.

Purpose of the Study:

  • To investigate the effectiveness of PCV in preventing influenza hospitalizations in children under 5.
  • To assess PCV benefit during the 2009-2010 pandemic and 2010-2011 influenza seasons in Spain.

Main Methods:

  • A multicenter matched case-control study was conducted in Spain from July 2009 to April 2011.
  • Cases were hospitalized children (6 months-5 years) with confirmed influenza; controls were matched for age, hospitalization date, and residence.
  • Adjusted odds ratios were calculated to determine the association between PCV vaccination and influenza hospitalization.

Main Results:

  • The study included 194 cases and 342 controls.
  • PCV vaccination showed a 48% adjusted benefit in preventing hospitalization during the 2009-2010 pandemic wave.
  • A negative benefit (-79%) was observed for PCV vaccination during the 2010-2011 influenza season.

Conclusions:

  • PCV vaccination was associated with reduced hospitalization in children under 5 during the 2009-2010 influenza pandemic wave.
  • No significant benefit of PCV vaccination in preventing hospitalization was observed during the 2010-2011 influenza season.
Abstract

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