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Antimicrobial susceptibilities of Clostridium difficile isolated in Japan

Hiroyuki Kunishima1, Junichi Chiba, Michiko Saito

  • 1Department of Infection Control and Laboratory Diagnostics, Internal Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan. h2kuni@med.tohoku.ac.jp

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|January 23, 2013
PubMed

Insights

All Japanese Clostridium difficile isolates were susceptible to metronidazole (MNZ) and vancomycin (VCM). Continuous monitoring is crucial as resistant strains may emerge, impacting antimicrobial-associated diarrhea treatment.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Clostridium difficile causes antimicrobial-associated diarrhea and nosocomial infections.
  • Metronidazole (MNZ) and vancomycin (VCM) are standard treatments.
  • Emergence of MNZ-resistant strains necessitates ongoing surveillance.

Purpose of the Study:

  • To determine the susceptibility of clinical Clostridium difficile isolates in Japan to various antimicrobial agents.
  • To assess the minimum inhibitory concentrations (MICs) of 15 drugs against C. difficile.

Main Methods:

  • Broth microdilution method was employed.
  • 157 clinical isolates of C. difficile from Japan were tested.
  • MICs for 15 different drugs were determined.

Main Results:

  • All 157 C. difficile isolates were susceptible to metronidazole (MNZ).
  • All isolates were also susceptible to vancomycin (VCM) and teicoplanin.
  • MIC ranges and MIC50/MIC90 values for MNZ, VCM, and teicoplanin were established.

Conclusions:

  • Current Japanese C. difficile isolates remain susceptible to MNZ and VCM.
  • Continuous monitoring of antimicrobial susceptibility is essential to detect potential resistance.
  • Proactive surveillance will guide future treatment strategies for C. difficile infections.

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