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Related Concept Videos

Antipsychotic Drugs: Typical and Atypical Agents01:21

Antipsychotic Drugs: Typical and Atypical Agents

Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
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Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
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Ziprasidone.

R Davis1, A Markham

  • 1Adis International Limited, 41 Centonan Drive, Private Bag 65901, Mairangi Bay, Auckland 10, New Zealand.

CNS Drugs
|January 23, 2013
PubMed
Summary
This summary is machine-generated.

Ziprasidone, an antipsychotic, shows effectiveness in treating schizophrenia symptoms and anxiety. It has a lower risk of motor side effects due to its specific receptor binding profile.

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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
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Area of Science:

  • Pharmacology
  • Neuroscience
  • Psychiatry

Background:

  • Ziprasidone is a novel antipsychotic medication.
  • It exhibits high affinity for serotonin 5-HT(2) and dopamine D(2) receptors.
  • Its pharmacological profile suggests a low potential for motor disturbances like extrapyramidal symptoms (EPS).

Purpose of the Study:

  • To evaluate the efficacy and tolerability of ziprasidone.
  • To investigate its effects on positive and negative symptoms of schizophrenia.
  • To assess its anxiolytic effects in patients undergoing dental surgery.

Main Methods:

  • In vitro receptor binding studies.
  • In vivo receptor binding studies.
  • Phase II and III clinical trials.

Main Results:

  • Ziprasidone demonstrated higher affinity for 5-HT(2) than D(2) receptors.
  • Clinical trials showed efficacy in reducing schizophrenia symptoms (positive and negative) and associated depression.
  • Ziprasidone was effective in reducing anxiety in dental surgery patients.
  • The drug was generally well tolerated, with somnolence and nausea as common adverse events; EPS were infrequent.

Conclusions:

  • Ziprasidone's unique receptor binding profile contributes to its efficacy and favorable motor side effect profile.
  • It is an effective treatment option for schizophrenia and anxiety.
  • Further research may explore its anxiolytic and antidepressant properties due to its serotonin and noradrenaline reuptake inhibition.