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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

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Related Experiment Video

Updated: May 15, 2026

Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum (Clove) and Cuminun cyminum (Cumin) on C57BL6/j Mice Fed High-Fat Diet
13:09

Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum (Clove) and Cuminun cyminum (Cumin) on C57BL6/j Mice Fed High-Fat Diet

Published on: July 31, 2021

Curcumin and obesity.

Peter G Bradford1

  • 1Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214-3000, USA. pgb@buffalo.edu

Biofactors (Oxford, England)
|January 23, 2013
PubMed
Summary
This summary is machine-generated.

Curcumin, a compound in turmeric, combats obesity by reducing inflammation in fat tissue. It inhibits inflammatory pathways and promotes anti-inflammatory agents, aiding weight management and reducing obesity-related health risks.

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An Acupoint Catgut-embedding Therapy for Treating Obesity
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An Acupoint Catgut-embedding Therapy for Treating Obesity

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Related Experiment Videos

Last Updated: May 15, 2026

Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum (Clove) and Cuminun cyminum (Cumin) on C57BL6/j Mice Fed High-Fat Diet
13:09

Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum (Clove) and Cuminun cyminum (Cumin) on C57BL6/j Mice Fed High-Fat Diet

Published on: July 31, 2021

An Acupoint Catgut-embedding Therapy for Treating Obesity
04:50

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

Area of Science:

  • Nutritional Science
  • Molecular Biology
  • Immunology

Background:

  • Turmeric is recognized for anti-inflammatory and health benefits.
  • Curcumin is a primary active compound in turmeric, known for its anti-inflammatory properties.
  • Obesity is linked to chronic low-grade metabolic inflammation.

Purpose of the Study:

  • Investigate curcumin's role in combating obesity.
  • Examine curcumin's direct effects on white adipose tissue.
  • Understand curcumin's anti-inflammatory mechanisms in obesity.

Main Methods:

  • Studied curcumin's interaction with white adipose tissue.
  • Assessed curcumin's impact on macrophage infiltration and NF-κB activation.
  • Analyzed changes in adipokine expression (TNFα, MCP-1, PAI-1, adiponectin).

Main Results:

  • Curcumin suppresses chronic inflammation in white adipose tissue.
  • Curcumin inhibits inflammatory mediators like NF-κB, TNFα, MCP-1, and PAI-1.
  • Curcumin promotes adiponectin expression and inhibits adipocyte differentiation.

Conclusions:

  • Curcumin effectively reduces obesity and related health issues.
  • Curcumin's anti-inflammatory actions in adipose tissue are key to its benefits.
  • Curcumin presents a potential therapeutic strategy for obesity management.