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Updated: May 15, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

mGlu5 negative allosteric modulators: a patent review (2010-2012).

Kyle A Emmitte1

  • 1Vanderbilt University Medical Center, Vanderbilt Center for Neuroscience Drug Discovery, Department of Chemistry, Nashville, TN 37232, USA. kyle.a.emmitte@vanderbilt.edu

Expert Opinion on Therapeutic Patents
|January 24, 2013
PubMed
Summary

Small molecule negative allosteric modulators (NAMs) targeting the metabotropic glutamate receptor subtype 5 (mGlu5) show promise for various neurological and psychiatric disorders. Continued chemical diversity in mGlu5 NAMs fuels optimism for future therapeutic development.

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