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Ambulatory systolic-diastolic pressure regression index predicts acute coronary syndromes

Wojciech Sobiczewski1, Marcin Wirtwein, Marcin Gruchala

  • 1Department of Cardiology, Medical University of Gdansk, Debinki 7, 80-211 Gdansk, Poland.

Blood Pressure
|January 24, 2013
PubMed

Insights

The ambulatory systolic-diastolic pressure regression index (ASDPRI) predicts acute coronary syndromes (ACS) in patients with coronary atherosclerosis. Higher ASDPRI indicates increased risk for cardiovascular events like ACS.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Vascular Medicine

Background:

  • The ambulatory systolic-diastolic pressure regression index (ASDPRI) is a composite marker reflecting cardiovascular properties.
  • Significant coronary atherosclerosis is a major risk factor for cardiovascular events.

Purpose of the Study:

  • To investigate the relationship between ASDPRI and cardiovascular events.
  • To determine if ASDPRI is an independent predictor of acute coronary syndromes (ACS) in patients with coronary atherosclerosis.

Main Methods:

  • Analyzed 891 patients undergoing diagnostic coronary angiography.
  • Calculated ASDPRI as 1 minus the slope of the linear relation between 24-h diastolic blood pressure (DBP) and 24-h systolic blood pressure (SBP).
  • Followed patients for a median of 6.7 years to record cardiovascular events.

Main Results:

  • 135 acute coronary syndromes (ACS), including 5 deaths and 55 strokes, occurred during follow-up.
  • Patients with ACS had a significantly higher 24-h ASDPRI (0.35 ± 0.1) compared to those without ACS (0.30 ± 0.1, p < 0.01).
  • 24-h ASDPRI was an independent predictor for ACS (OR = 4.0; 95% CI 1.3-12.0).

Conclusions:

  • ASDPRI plays a significant role as a risk factor for ACS.
  • ASDPRI is a valuable prognostic marker in patients with established coronary atherosclerosis.
Abstract

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