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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

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Related Experiment Video

Updated: May 14, 2026

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
07:45

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis

Published on: January 26, 2024

Lymphotoxin network pathways shape the tumor microenvironment.

Ryan L Bjordahl1, Christian Steidl, Randy D Gascoyne

  • 1Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Research Institute, 10901N. Torrey Pines Road, La Jolla, CA 92037, USA.

Current Opinion in Immunology
|January 24, 2013
PubMed
Summary
This summary is machine-generated.

Lymphotoxin-beta (LT-β) cytokines influence cancer cell behavior and the tumor microenvironment. Targeting the LT network offers a novel therapeutic strategy against cancer progression and tumor-permissive environments.

Related Experiment Videos

Last Updated: May 14, 2026

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
07:45

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis

Published on: January 26, 2024

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • Lymphotoxin (LT)-β related cytokines are integral to immune system regulation, particularly in lymphoid organ development and homeostasis.
  • The LT network orchestrates inflammatory responses crucial for host defense against pathogens.
  • Emerging evidence suggests a significant role for LT cytokines in cancer biology.

Purpose of the Study:

  • To review the current understanding of the Lymphotoxin (LT) Network's involvement in cancer development and progression.
  • To highlight the potential of manipulating the LT Network as a therapeutic strategy in oncology.
  • To explore how LT cytokines impact tumor cell phenotype and the tumor microenvironment.

Main Methods:

  • Literature review of existing research on Lymphotoxin-beta cytokines and cancer.
  • Analysis of studies investigating the role of the LT network in immune responses and cancer progression.
  • Synthesis of evidence linking LT network activity to tumor microenvironment modulation.

Main Results:

  • Lymphotoxin (LT)-β cytokines directly influence cancer cell characteristics.
  • The LT network plays a critical role in shaping the tumor microenvironment.
  • Dysregulation of the LT network is implicated in the progression of various cancers, including lymphoma.

Conclusions:

  • The Lymphotoxin (LT) Network is a key player in cancer development and progression.
  • Modulating the LT Network presents a promising avenue for cancer therapy.
  • Targeting tumor-permissive microenvironments via the LT network could offer specific anti-cancer strategies.