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Updated: May 14, 2026

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
Published on: July 11, 2015
Interferon γ in patients with HIV/AIDS and suspicion or latent tuberculosis infection
Guadalupe García-Elorriaga1, Mayté Martínez-Velázquez, Verónica Gaona-Flores
1Unidad de Investigación en Inmunología e Infectología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social Mexico City, Mexico. gelorriaga@webtelmex.net.mx
Objective:
To assess the usefulness of IGRA test (QuantiFERON(®)-Cell mediated immune) compared with the tuberculin skin test.
Methods:
A cross-sectional study was carried out in Mexico, 25 infected patients with HIV-AIDS and the suspicion or with latent tuberculous infection (LTBI) who were >18 years of age and without treatment for tuberculosis (TB), were enrolled in the study.
Results:
Median cluster of differentiation (CD4) count was 364 cells/μ L and median HIV viral load was 50 copies/mL. Overall, 20 patients (80%) had at least one positive diagnostic test for LTBI: four (16%) had a positive tuberculin skin test and 19 (76%), a positive QuantiFERON(®)-tuberculosis.
Conclusions:
No agreement is found between the two diagnostic tests: k = -0.004, 95% confidence interval (-0.2219, 0.2210). Additional longitudinal studies among HIV-infected populations with high prevalence of TB are needed to further assess the usefulness of IGRAs in this patient population.
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