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Related Experiment Video

Updated: May 14, 2026

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
09:15

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Published on: May 23, 2014

Research resource: the Endometrium Database Resource (EDR).

Yolanda Darlington1, Jae-Wook Jeong, Kevin Y Lee

  • 1Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

Molecular Endocrinology (Baltimore, Md.)
|January 24, 2013
PubMed
Summary
This summary is machine-generated.

The Endometrium Database Resource (EDR) consolidates scattered endometrial gene expression data. This accessible tool aids research into uterine biology and disease treatments.

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Area of Science:

  • Reproductive Biology
  • Genomics
  • Bioinformatics

Background:

  • Understanding endometrial gene expression is crucial for diagnosing and treating uterine diseases.
  • Existing gene expression data is fragmented across multiple resources, hindering accessibility for researchers.
  • A centralized, integrated resource is needed to facilitate the study of uterine gene regulation.

Purpose of the Study:

  • To create a unified database resource for endometrial gene expression data.
  • To provide a user-friendly platform for querying, integrating, and analyzing uterine gene regulation information.
  • To support research into endometrial biology and the development of novel diagnostic and therapeutic strategies.

Main Methods:

  • Compiled data on protein- and micro-RNA-encoding genes with documented uterine expression regulation from literature.
  • Integrated gene expression data from various experimental methods including microarrays and Northern blots.
  • Annotated genes with essential information, orthologs, and gene ontologies, linking to external databases.

Main Results:

  • Developed the Endometrium Database Resource (EDR), a comprehensive, web-based platform.
  • EDR includes annotations for basic gene information, orthologs, and gene ontologies.
  • The resource enables direct comparison of relative gene expression across different microarray experiments.

Conclusions:

  • The Endometrium Database Resource (EDR) provides a valuable, freely accessible tool for the scientific community.
  • EDR simplifies the investigation of uterine gene expression and regulation.
  • This resource facilitates advancements in understanding endometrial biology and developing treatments for uterine diseases.