Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
Bioavailability: Overview01:17

Bioavailability: Overview

Bioavailability refers to the proportion of an administered drug that reaches the systemic circulation in its active, unaltered form. It is a crucial pharmacokinetic parameter that determines the effectiveness of a drug in achieving its intended therapeutic outcomes. The route of administration significantly influences bioavailability, with intravenous administration achieving 100% bioavailability as the drug directly enters the bloodstream. In contrast, oral administration often results in...
Bioavailability: Overview01:13

Bioavailability: Overview

Bioavailability refers to the proportion of an unaltered drug that, after administration, enters the systemic circulation and can be distributed to the desired action site. Factors such as gastrointestinal (GI) absorption and liver biotransformation influence the bioavailability of a drug when it is administered orally. When a drug is administered intravenously, it enters the systemic circulation directly; by definition, its bioavailability is assumed to be 100%. The bioavailability of an...
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
Modified-Release Drug Delivery Systems: Bioavailability01:30

Modified-Release Drug Delivery Systems: Bioavailability

Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...
Measurement of Bioavailability: Pharmacodynamic Methods01:20

Measurement of Bioavailability: Pharmacodynamic Methods

Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The potential of clay- and zeolite-based materials used in agricultural systems: Insights into greenhouse gas emission mitigation.

The Science of the total environment·2026
Same author

Microbial-Plant Synergy Underpins the Mitigation of Atrazine Phytotoxicity in Soybean by a Multifunctional Bacterial Seed Coating.

Journal of agricultural and food chemistry·2026
Same author

PFAS-free alternatives for sustainable applications: Sector-specific solutions and global perspectives.

Chemosphere·2026
Same author

Boosting sulfamethoxazole degradation via peroxymonosulfate activation: Critical comparison of intrinsic and external nitrogen-doped biochar modulated by pore former.

Journal of hazardous materials·2026
Same author

Metal-induced balancing of conjugation and planarity in porphyrin-based monomers to construct the highly crystalline covalent organic frameworks with outstanding visible-light catalytic activity.

Journal of colloid and interface science·2026
Same author

Biotechnologies for removal of per- and polyfluoroalkyl substances (PFAS) in biosolids: Current status and challenges.

Journal of environmental management·2026
Same journal

Coexisting pollutants modulate cephalosporin bioavailability and shape antibiotic resistance evolution under co-exposure conditions.

Journal of hazardous materials·2026
Same journal

PM<sub>2.5</sub> chemical constituents and chronic obstructive pulmonary disease mortality risk: The Pearl River Cohort study.

Journal of hazardous materials·2026
Same journal

Dissolved organic matter composition influences catalytic oxidation behavior and product evolution in real water matrices.

Journal of hazardous materials·2026
Same journal

Impact of fulvic acid on copper exposure in Ulva prolifera: Integrative insights from growth, physiology, transcriptomics, and physico-chemical characteristics.

Journal of hazardous materials·2026
Same journal

Atmospheric versus soil Cadmium exposure in rice (Oryza sativa L.): Divergent toxicological mechanisms and human health risks via integrated multi-omics.

Journal of hazardous materials·2026
Same journal

Widespread bisphenol S analogues in E-waste recycling dust and air: Gas-particle partitioning behavior and human exposure implications.

Journal of hazardous materials·2026
See all related articles

Related Experiment Video

Updated: May 14, 2026

A Whole Cell Bioreporter Approach to Assess Transport and Bioavailability of Organic Contaminants in Water Unsaturated Systems
13:16

A Whole Cell Bioreporter Approach to Assess Transport and Bioavailability of Organic Contaminants in Water Unsaturated Systems

Published on: December 24, 2014

Bioavailability as a tool in site management.

Joop Harmsen1, Ravi Naidu

  • 1Alterra, Wageningen UR, P.O. Box 47, 6700 AA Wageningen, The Netherlands.

Journal of Hazardous Materials
|January 24, 2013
PubMed
Summary
This summary is machine-generated.

Understanding contaminant bioavailability is key for environmental risk assessment and effective remediation. Applying bioavailability principles reduces risks and costs in managing polluted sites, though regulatory acceptance remains a challenge.

Keywords:
AssessmentBioavailabilityRemediationRisk reductionSedimentSoil

More Related Videos

Deployment and Retrieval of Mineral Samplers
05:52

Deployment and Retrieval of Mineral Samplers

Published on: January 20, 2026

Related Experiment Videos

Last Updated: May 14, 2026

A Whole Cell Bioreporter Approach to Assess Transport and Bioavailability of Organic Contaminants in Water Unsaturated Systems
13:16

A Whole Cell Bioreporter Approach to Assess Transport and Bioavailability of Organic Contaminants in Water Unsaturated Systems

Published on: December 24, 2014

Deployment and Retrieval of Mineral Samplers
05:52

Deployment and Retrieval of Mineral Samplers

Published on: January 20, 2026

Area of Science:

  • Environmental Science
  • Risk Assessment
  • Remediation Technologies

Background:

  • Bioavailability is crucial for assessing environmental and human health risks from contaminants.
  • Measuring bioavailability aids in realistic risk appraisals at polluted sites.
  • Contaminant dispersal and toxicity are directly linked to bioavailability.

Purpose of the Study:

  • To demonstrate the application of bioavailability principles in risk-based remediation.
  • To highlight cost-effective and in situ management strategies for contaminated sites.
  • To present case studies of bioavailability-informed remediation projects.

Main Methods:

  • Risk-based approaches incorporating bioavailability measurements.
  • Case studies involving organic contaminants (PAHs, pesticides, PFOS) and heavy metals.
  • Field projects conducted in The Netherlands, Mali, Mauretania, Australia, and Taiwan.

Main Results:

  • Bioavailability principles enable realistic risk assessments.
  • Remediation practices based on bioavailability reduce contaminant risks and costs.
  • Successful application demonstrated across diverse contaminants and international sites.

Conclusions:

  • Integrating bioavailability into risk assessment offers cost-effective, in situ management of contaminated sites.
  • Bioavailability-guided remediation strategies are effective in reducing environmental and health risks.
  • Regulatory and public acceptance are critical barriers to widespread adoption of these strategies.