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Inflammatory bowel disease in Chinese children: a multicenter analysis over a decade from Shanghai
Xin-qiong Wang1, Yin Zhang, Chun-di Xu
1Department of Pediatrics, Shanghai Ruijin Hospital Affiliated with the School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Insights
Childhood inflammatory bowel disease (IBD) incidence steadily increased in Shanghai from 2000-2010. This trend highlights the need for further research into risk factors for pediatric IBD in China.
Area of Science:
- Pediatric Gastroenterology
- Epidemiology
- Inflammatory Bowel Disease Research
Background:
- Childhood inflammatory bowel disease (IBD) poses a growing global health concern.
- Understanding the epidemiological trends of pediatric IBD is crucial for public health planning.
Purpose of the Study:
- To estimate the incidence and characteristics of childhood inflammatory bowel disease (IBD) in Shanghai, China.
- To analyze trends in pediatric IBD from 2000 to 2010.
Main Methods:
- Retrospective, multicenter hospital-based study.
- Inclusion of IBD patients aged 0-18 years identified via computerized medical records.
- Extraction of relevant data from patient medical records.
Main Results:
- A total of 153 pediatric IBD cases were identified (107 males, 46 females).
- Crohn's disease (CD) accounted for 82 cases and ulcerative colitis (UC) for 71 cases.
- A steady annual increase in IBD incidence was observed in children aged 0-14 years, with peak prevalence in the 10-14 age group. Common symptoms included diarrhea, bloody stool, and abdominal pain.
Conclusions:
- A significant, steady increase in childhood IBD incidence was observed in Shanghai over a decade.
- The findings suggest a potential rise in pediatric IBD in China.
- Further population-based epidemiological studies are recommended to investigate the underlying risk factors.
Background:
The purpose was to estimate the incidence and characteristics of childhood inflammatory bowel disease (IBD) during 2000-2010 in Shanghai, China.
Methods:
IBD patients between the ages of 0 and 18 years old were identified by survey of computerized medical information. Relevant data were extracted from their corresponding medical records.
Results:
A total of 153 IBD cases were included in the study. Among them, 107 were males and 46 were females (male/female ratio, 2.3:1.0). Eighty-two had Crohn's disease (CD) and 71 had ulcerative colitis (UC). The peak prevalence of IBD was observed in the 10-14-year-old age group. The annual incidence of IBD in the 0 to 14 years age group of Shanghai residents steadily increased from 2000 to 2010. The most common symptoms of IBD were diarrhea (68.6%), bloody stool (68.6%), and abdominal pain (61.4%). More CD than UC patients had anemia and raised erythrocyte sedimentation rate and C-reactive protein levels. Ileocolonic type disease was more common in CD patients, and left-side colon involvement was more common in UC. Of all CD patients, 33 had mild active disease and 49 had moderate/severe disease. In UC patients, 34 were mild and 37 were moderate/severe disease.
Conclusions:
This retrospective, multicenter hospital-based study over a decade shows a steadily increasing trend of childhood IBD in China. This suggests a need for population-based epidemiological studies to explore the risk factors.
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