Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Polymer Classification: Architecture01:14

Polymer Classification: Architecture

Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
Design Consideration01:22

Design Consideration

Designing a structure involves a series of considerations, primarily the material's ultimate strength, calculated through tests that measure changes under increased force until the material reaches its breaking point or limit. The ultimate load, where the material breaks, is divided by its original cross-sectional area, resulting in the ultimate normal stress or strength. The ultimate shearing stress is another significant factor taken into account.
The factor of safety is another key aspect...
Design Example: Designing a Residential Plumbing System01:25

Design Example: Designing a Residential Plumbing System

The design of residential plumbing systems requires carefully evaluating water demand, flow rates, and pressure dynamics to ensure both efficiency and reliability. The nature of water flow within pipes is defined by its Reynolds number, which classifies flow as either laminar (smooth) or turbulent.
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
The Nucleus01:32

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Methionine Deprivation-induced Reprogramming of Hepatic Rhythms Is Mediated by Glucocorticoid Receptor.

bioRxiv : the preprint server for biology·2026
Same author

Discovery of Small-Molecule Antagonists of PHF1 and 19 Demonstrates the Ligandability of PRC2 Accessory Proteins.

ACS bio & med chem Au·2026
Same author

Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes.

Molecular cell·2026
Same author

Recruitment of BRD4 to the ASXL1 genomic targets depends on the extra-terminal domain of BRD4.

Nature communications·2026
Same author

A tryptophan-phenylalanine binding motif for the histone methyltransferases MLL4 and MLL3.

The Journal of biological chemistry·2026
Same author

HP1γ self-assembles and cooperates with KAP1 in repression of long noncoding RNA AI662270 in ESCs.

Cell reports·2026
Same journal

Elektra-Qki and Alien-Wt1 lncRNA-protein interaction controls myocardial ion channel expression and epicardial EMT during heart development in mice.

Cellular and molecular life sciences : CMLS·2026
Same journal

SHIP1 is required for T cell surveillance of occult malignancies.

Cellular and molecular life sciences : CMLS·2026
Same journal

Reply to: Commentary on "The food additive 4-hexylresorcinol impairs intestinal stem cell function and exacerbates inflammatory bowel disease in Drosophila melanogaster via suppression of MAPK signaling pathway".

Cellular and molecular life sciences : CMLS·2026
Same journal

The BmCPV-derived viral small peptide vsp1S4(-) suppresses viral replication by triggering apoptosis via the ROS-JNK signalling pathway.

Cellular and molecular life sciences : CMLS·2026
Same journal

UBE2L6 promotes invasion and metastasis of triple-negative breast cancer by enhancing autophagy through STK38 ISGylation.

Cellular and molecular life sciences : CMLS·2026
Same journal

Inhibition of ferroptosis via SLC25A39-NRF2 axis drives Osimertinib resistance in lung adenocarcinoma.

Cellular and molecular life sciences : CMLS·2026
See all related articles

Related Experiment Video

Updated: May 14, 2026

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

The NuRD architecture.

Hillary F Allen1, Paul A Wade, Tatiana G Kutateladze

  • 1Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

Cellular and Molecular Life Sciences : CMLS
|January 24, 2013
PubMed
Summary
This summary is machine-generated.

The nucleosome remodeling and deacetylase (NuRD) complex, with its dual enzymatic activity, plays a key role in gene regulation and development. Understanding NuRD subunit interactions is crucial for deciphering its diverse biological functions.

More Related Videos

Executing Complexity-Increasing Queries in Relational (MySQL) and NoSQL (MongoDB and EXist) Size-Growing ISO/EN 13606 Standardized EHR Databases
07:26

Executing Complexity-Increasing Queries in Relational (MySQL) and NoSQL (MongoDB and EXist) Size-Growing ISO/EN 13606 Standardized EHR Databases

Published on: March 19, 2018

Artificial Intelligence Approaches to Assessing Primary Cilia
08:58

Artificial Intelligence Approaches to Assessing Primary Cilia

Published on: May 1, 2021

Related Experiment Videos

Last Updated: May 14, 2026

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Executing Complexity-Increasing Queries in Relational (MySQL) and NoSQL (MongoDB and EXist) Size-Growing ISO/EN 13606 Standardized EHR Databases
07:26

Executing Complexity-Increasing Queries in Relational (MySQL) and NoSQL (MongoDB and EXist) Size-Growing ISO/EN 13606 Standardized EHR Databases

Published on: March 19, 2018

Artificial Intelligence Approaches to Assessing Primary Cilia
08:58

Artificial Intelligence Approaches to Assessing Primary Cilia

Published on: May 1, 2021

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cellular Biology

Background:

  • The nucleosome remodeling and deacetylase (NuRD) complex is a key regulator of chromatin organization.
  • It influences critical cellular processes including gene transcription, genomic stability, and developmental signaling.
  • NuRD possesses unique dual enzymatic activities, featuring both ATPase and histone deacetylase functions within its core subunits.

Purpose of the Study:

  • To review the structures and biological roles of the individual NuRD complex subunits.
  • To explore the interplay between NuRD subunits and its impact on complex function.
  • To identify new research directions for understanding the NuRD-mediated signaling network.

Main Methods:

  • Literature review of recent studies on the NuRD complex.
  • Analysis of structural and functional data of NuRD subunits.
  • Synthesis of current knowledge on NuRD-mediated signaling pathways.

Main Results:

  • NuRD complex composition and subunit interactions are critical determinants of its diverse functions.
  • Each of the six core subunits contributes uniquely to the complex's overall activity.
  • The interplay between subunits dictates the specific roles NuRD plays in various cellular contexts.

Conclusions:

  • Further investigation into NuRD subunit dynamics and interactions is essential.
  • Understanding the NuRD-mediated signaling network holds promise for therapeutic interventions.
  • This review provides a foundation for future research into the multifaceted roles of the NuRD complex.