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Updated: May 14, 2026
Three-Dimensional In Vitro Biomimetic Model of Neuroblastoma Using Collagen-Based Scaffolds
Published on: July 9, 2021
Outcome of neuroblastoma in India
Ketan Prasad Kulkarni1, Ram Kumar Marwaha
1Division of Pediatric Hematology Oncology, Stollery Children Hospital, University of Alberta, Edmonton, AB, Canada, ketanpkulkarni@gmail.com.
Insights
Childhood neuroblastoma outcomes in India show significant variation, with high death and relapse rates. Improving diagnostics, therapy, and support systems is crucial for better pediatric cancer care.
Area of Science:
- Pediatric Oncology
- Cancer Research
- Clinical Outcomes
Background:
- Childhood neuroblastoma presents a significant oncological challenge globally.
- Outcomes for pediatric cancers can vary widely based on geographic location and healthcare infrastructure.
Purpose of the Study:
- To evaluate the outcomes of childhood neuroblastoma in India over the past two decades.
- To identify gaps in neuroblastoma management and propose solutions.
- To provide insights into pediatric cancer care in resource-limited settings.
Main Methods:
- A systematic literature review was conducted to gather data on childhood neuroblastoma outcomes in India.
- Hand searches of International Society of Paediatric Oncology and American Society of Clinical Oncology abstracts were performed to include unpublished data.
- Clinico-demographic and outcome data were extracted from identified studies.
Main Results:
- Data from approximately 700 patients across multiple centers over 20 years were analyzed.
- Predominantly Stage III/IV neuroblastoma cases were reported, treated with non-myeloablative chemotherapy and surgery.
- Reported survival rates ranged from 8.7% to 80%, with high rates of mortality, relapse, disease progression, and treatment abandonment.
- Limited diagnostic facilities and inadequate treatment for high-risk cases were noted.
Conclusions:
- There is a critical need to standardize and improve neuroblastoma treatment protocols across Indian cancer centers.
- Enhancing diagnostic capabilities, laboratory facilities, and supportive care is essential.
- Implementing a national data management system and improving financial/social support are vital for better pediatric cancer outcomes.
Objectives:
To assess the outcome of childhood neuroblastoma in India over the last 2 decades, identify management lacunae and suggest remedial measures.
Methods:
A comprehensive search to identify literature addressing outcome of childhood neuroblastoma from India was performed. International Society of Paediatric Oncology and American Society of Clinical Oncology Annual-Meeting abstracts were hand searched to identify unpublished data. Clinico-demographic and outcome data was extracted.
Results:
Outcome of approximately 700 patients has been published over the last 2 decades with predominantly small to moderate single center series from 6 cities. Primarily non-myeloablative multiagent chemotherapy protocols alongwith surgery, have been used for treatment. A large majority of patients had stage III/IV neuroblastoma. Limited diagnostic facilities were available at most centers. Survival outcome of 8.7 to 80 % has been reported with high death and relapse rates alongwith high incomplete control/disease progression and treatment abandonment. Few series have identified prognostic parameters. Few patients with high-risk disease have been adequately treated and cured.
Conclusions:
There is a clear need for replicating neuroblastoma outcomes at centers of excellence in other cancer centers, improving diagnostic and laboratory facilities, administering adequate and appropriate contemporary therapy, assessing disease response and improving supportive care. National data management infrastructure along with better financial and social support initiatives are key factors.