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Updated: May 14, 2026
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Published on: September 13, 2022
Effectiveness of 17-α-hydroxyprogesterone caproate on preterm birth prevention in women with history-indicated
A Dhanya Mackeen1, Timothy J Rafael, Jillian Zavodnick
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.
Objective:
To determine whether 17-α-hydroxyprogesterone caproate (17P) reduces the incidence of preterm birth in women with a history-indicated cerclage.
Study Design:
Retrospective cohort study of women who received a cerclage for a prior preterm birth, analyzed based on exposure to 17P. The primary outcome variable was delivery < 35 weeks. Secondary outcomes were preterm birth < 37, 32, 28, and 24 weeks; interval between cerclage placement and delivery; gestational age at delivery; and infant birth weight.
Results:
Fourteen women received 17P and 80 did not. Baseline characteristics did not differ between these two groups. Preterm delivery at < 35 weeks did not differ between those who received 17P and those who did not (29% versus 15%, p = 0.46). There were no significant differences between the groups for any other outcome.
Conclusion:
17P does not appear to have an effect on preterm birth < 35 weeks in women with a history-indicated cerclage.
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