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Updated: May 14, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
A robust route to enzymatically functional, hierarchically self-assembled peptide frameworks
S Sangiambut1, K Channon, N M Thomson
1Biological and Soft Systems, Cavendish Laboratory, University of Cambridge, CB3 0HE, UK.
Abstract:
The addition of enzyme biofunctionality to self-assembling peptide nanofibers is challenging since such additions can inhibit functionality or self-assembly. We introduce a method for peptide nanofiber enzyme functionalization, demonstrated by the attachment of a polymerization synthase to peptide nanofibers. The enzyme generates a biocompatible, biodegradable biopolyester coat on the fibers with applicablity in medical engineering. This approach provides a template for generation of functional bionanomaterials.
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