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Influence of N substitution on antimycobacterial activity of ciprofloxacin
A Haemers1, D C Leysen, W Bollaert
1Department of Pharmaceutical Sciences, University of Antwerp, Belgium.
Antimicrobial Agents and Chemotherapy
|March 1, 1990
Abstract:
Ciprofloxacin analogs with various substitutions on the piperazine nitrogen were tested against several mycobacteria. In contrast to what has been found with other gram-positive and gram-negative bacteria, alkyl analogs such as N-isopropylciprofloxacin were shown to be significantly more active than ciprofloxacin. MICs of 0.125 microgram/ml against Mycobacterium tuberculosis were found.