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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Video

Updated: May 14, 2026

A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment
10:39

A Label-Free Segmentation Approach for Intravital Imaging of Mammary Tumor Microenvironment

Published on: May 24, 2022

Optical imaging of tumor microenvironment.

Yihan Wu1, Wenjie Zhang, Jinbo Li

  • 1School of Chemistry and Chemical Engineering, Key Lab of Analytical Chemistry for Life Science, Ministry of Education of China, Nanjing University Nanjing, China.

American Journal of Nuclear Medicine and Molecular Imaging
|January 24, 2013
PubMed
Summary

This review highlights fluorescent probes for optical imaging of the tumor microenvironment. These probes target key features like acidity, hypoxia, and proteases, aiding in tumor diagnosis and treatment strategies.

Keywords:
Optical imaginghypoxiapHproteasetumor microenvironment

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Last Updated: May 14, 2026

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Area of Science:

  • Biomedical Imaging
  • Oncology
  • Chemical Biology

Background:

  • The tumor microenvironment (TME) significantly influences tumor progression and metastasis.
  • Key TME characteristics like acidity, hypoxia, and protease overexpression differ from normal tissues.
  • These TME features are crucial biomarkers and therapeutic targets.

Purpose of the Study:

  • To review recent advancements in fluorescent probes for optical imaging of the TME.
  • To discuss the design strategies for fluorescent probes targeting TME hallmarks.
  • To explore the application of these probes in visualizing tumor cells and tissues.

Main Methods:

  • Focus on fluorescent probes designed for optical imaging.
  • Probes are engineered to detect specific TME features: pH, hypoxia, and proteases.
  • Review of probe construction strategies and their imaging applications.

Main Results:

  • Development of diverse fluorescent probes tailored to TME characteristics.
  • Demonstration of optical imaging capabilities for TME analysis.
  • Successful application of probes in visualizing tumor-specific conditions.

Conclusions:

  • Fluorescent probes offer powerful tools for optical imaging of the TME.
  • Targeting TME features with probes facilitates tumor diagnosis and therapeutic development.
  • Continued innovation in probe design will enhance TME investigation.