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Updated: May 14, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
Epstein-Barr Virus (EBV)-associated gastric carcinoma
Hisashi Iizasa1, Asuka Nanbo, Jun Nishikawa
1Division of Stem Cell Biology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo 060-0815, Japan. iizasah@igm.hokudai.ac.jp
Epstein-Barr virus (EBV) is linked to gastric cancer, comprising 10% of cases. This review explores EBV-gastric carcinoma, its characteristics, and potential therapies.
Area of Science:
- Oncology
- Virology
- Genetics
Background:
- Epstein-Barr virus (EBV) is associated with lymphoid and epithelial malignancies.
- EBV infects memory B cells, activating pathways that can lead to B cell lymphomagenesis.
- The exact role of EBV in epithelial tumor carcinogenesis is not fully understood.
Purpose of the Study:
- This review focuses on the characteristics and current understanding of EBV-associated gastric carcinoma.
- To present the definition, epidemiology, and clinical features of EBV-gastric carcinoma.
- To discuss the route of infection, carcinogenic role of viral genes, genomic methylation, and miRNA in EBV-gastric carcinoma.
Main Methods:
- Literature review and synthesis of current research on EBV-associated gastric carcinoma.
- Analysis of epidemiological data, clinical features, and viral gene expression patterns.
- Exploration of the role of genomic CpG methylation and microRNAs (miRNAs) in carcinogenesis.
Main Results:
- EBV-associated gastric carcinoma accounts for approximately 10% of all gastric carcinoma cases.
- These tumors characteristically express restricted EBV latent genes (Latency I).
- Frequent genomic CpG methylation and specific miRNA roles are associated with EBV-gastric carcinoma carcinogenesis.
Conclusions:
- EBV plays a significant role in the development of a subset of gastric carcinomas.
- Understanding EBV's carcinogenic mechanisms, including genomic alterations and miRNA involvement, is crucial.
- Therapeutic strategies targeting EBV-associated gastric carcinoma are being explored.
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