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Updated: May 14, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
Endocytic pathways involved in filovirus entry: advances, implications and future directions
Suchita Bhattacharyya1, Nirupama Mulherkar, Kartik Chandran
1University of Mumbai and Department of Atomic Energy-Centre for Excellence in Basic Sciences, Health Centre Building, Vidyanagari, Kalina, Santacruz East, Mumbai 400098, India. bsuchita@gmail.com
Abstract:
Detailed knowledge of the host-virus interactions that accompany filovirus entry into cells is expected to identify determinants of viral virulence and host range, and to yield targets for the development of antiviral therapeutics. While it is generally agreed that filovirus entry into the host cytoplasm requires viral internalization into acidic endosomal compartments and proteolytic cleavage of the envelope glycoprotein by endo/lysosomal cysteine proteases, our understanding of the specific endocytic pathways co-opted by filoviruses remains limited. This review addresses the current knowledge on cellular endocytic pathways implicated in filovirus entry, highlights the consensus as well as controversies, and discusses important remaining questions.
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